My research interests are interdisciplinary, with a focus on neuroendocrine modulation of endocrine and behavioral components of reproduction. This has led my lab to studies on the role of hormones in sexual differentiation, impacts of endocrine disrupting chemicals and processes involved in aging. Some of these interests have translated into a long-standing collaboration with the National Zoo on conservation of threatened and endangered wildlife using reproductive technologies. Our studies have also considered the effects of nutrition on reproductive and metabolic aging in the rhesus macaque. We have just completed a series of studies on effects of estrogens in neurodegenerative disease in a mouse model of Alzheimer’s disease. These interests are co-mingled in studies on the consequences of early embryonic and lifetime exposures to environmental endocrine disruptors on reproductive aging and overall individual health in wildlife and domestic species.